分子神経生物学研究室

原著論文

• 2021
  Mizuno Y, Konishi S, Imai H, Fujimori E, Kojima N, Kajiwara C, Yoshinaga J
  "Telomere length and urinary 8-hydroxy-2’-deoxyguanosine and essential trace element concentrations in female Japanese university students."
  J Environmental Science and Health (Part A) 56:1328-1334.
• 2021
  Seidl MD, Fels B, Kranick D, Sternberg A, Grimm K, Stümpel FT, Pluteanu F, Schulte JS, Heinick A, Kojima N, Endo S, Huge A, Stoll M, Müller FU
  "Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation."
  FASEB Journal doi: 10.1096/fj.201902301RR.
• 2019
  Mizuno Y, Konishi S, Imai H, Fujimori E, Kojima N, Yoshinaga J
  "Cadmium exposure and blood telomere length in female University students in Japan."
  Biol Trace Elem Res doi: 10.1007/s12011-019-1656-3.
• 2018
  Yasuda H, Kojima N, Hanamura K, Yamazaki H, Sakimura K, Shirao T.
  "Drebrin isoforms critically regulate NMDAR- and mGluR-dependent LTD induction."
  Front Cell Neurosci 12: 330.
• 2018
  Bohn T, Rapp S, Luther N, Klein M, Bruehl T-J, Kojima N el al.
  "Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages."
  Nature Immunol 19: 1319–1329.
• 2018
  Hanamura K, Kamata Y, Yamazaki H, Kojima N, Shirao T.
  "Isoform-dependent regulation of drebrin dynamics in dendritic spines."
  Neuroscience 379: 67–76.
• 2017
  Kajita Y, Kojima N, Koganezawa N, Yamazaki H, Sakimura K, Shirao T.
  "Drebrin E regulates neuroblast proliferation and chain migration in the adult brain."
  Eur J Neurosci 46: 2214–2228.
• 2016
  Kojima N, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T.
  "Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice."
  Neuroscience 324: 218–226.
• 2016
  Puspitasari A, Koganezawa N, Ishizuka Y, Kojima N, Tanaka N, Nakano T, Shirao T.
  "X-irradiation induces acute cognitive decline via transient synaptic dysfunction."
  Radiation Research 185: 423–430.
• 2015
  Maekawa M, Iwayama Y, Ohnishi T, Toyoshima M, Shimamoto C, Hisano Y, Toyota T, Balan S, Matsuzaki H, Iwata Y, Takagai S, Yamada K, Ota M, Fukuchi S, Okada Y, Akamatsu W, Tsujii M, Kojima N, Owada Y, Okano H, Mori N, Yoshikawa T.
  "Investigation of the fatty acid transporter-encoding genes SLC27A3 and SLC27A4 in autism."
  Scientific Reports 5: 16239.
• 2014
  Yamazaki H, Kojima N, Kato K, Hirose H, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T.
  "Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines."
  Journal of Neurochemistry 128: 507–522.
• 2014
  Mizui T, Sekino Y, Yamazaki H, Ishizuka Y, Takahashi H, Kojima N, Kojima M and Shirao T.
  "Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines."
  PLoS ONE 9: e85367.
• 2013
  Roppongi RT, Kojima N, Hanamura K, Yamazaki H, Shirao T.
  "Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors."
  Neuroscience Letters 547: 76–81.

学会発表

• 2021年7月
  Yoshida A, Kojima N.
  "Impaired olfactory-dependent neural activity in drebrin knockout mice."
  The 44th Annual Meeting of the Japan Neuroscience Society/The 1st CJK International Meeting (Online meeting)
• 2021年1月
  児島　伸彦
  "ストレスの脳機能への影響に関する基礎研究―脳腸相関との関係."
  第11回 フェルラ酸・グリア研究会, AP日本橋
• 2020年3月
  Kato R, Kojima N.
  "Heat stress-induced cognitive dysfunction is caused by changes in the gut microbiota. "
  第98回 日本生理学会大会（Web開催）
• 2020年3月
  Sawabe M, Kojima N.
  "Changes in spine morphology and learning behavior in drebrin knockout mice."
  第98回 日本生理学会大会（Web開催）
• 2019年3月
  Kojima N, Sawabe M, Shu Kaiin, Hanamura K, Shirao T.
  "The activity of metabotropic glutamate receptor affects drebrin localization in dendritic spines."
  9th FAOPS congress Kobe
• 2018年9月
  Shiraishi K, Kojima N.
  "Prenatal exposure to sodium valproate causes synaptic abnormality and gene expression changes in the brain."
  WFSBP 2018 Kobe
• 2018年1月
  児島 伸彦
  "フェルガードのマウス神経細胞および高次脳機能に及ぼす効果"
  第5回 フェルラ酸研究会, TKPガーデンシティ品川
• 2017年7月
  Shiraishi K, Urushiyama R, Yamazaki R, Kaneko S, Oka Y, Kojima N.
  "Prenatal exposure of mice to sodium valproate causes synaptic abnormality and change in gene expression in the brain.（胎生期バルプロ酸ナトリウム曝露マウスのシナプス異常と遺伝子発現変化）"
  第40回 日本神経科学大会, 幕張メッセ
• 2017年7月
  Kojima N, Yasuda H, Sakimura K, Shirao T.
  "Impact of drebrin-knockout on mGluR5- and NMDAR-dependent LTD induction in the hippocampus.（ドレブリンノックアウトが海馬におけるmGluR5およびNMDAR依存性LTD誘導に及ぼす影響）"
  第40回 日本神経科学大会, 幕張メッセ
• 2016年7月
  Kakegawa R, Shiraishi K, Kojima N.
  "Impact of molecular interactions of metabotropic glutamate receptor and drebrin on synaptic structural plasticity in hippocampal neurons."
  第39回 日本神経科学大会, パシフィコ横浜
• 2015年9月
  Kakegawa R, Kamasaki S, Todoriki T, Kojima N.
  "The role of metabotropic glutamate receptor on structural plasticity of dendritic spines in cultured hippocampal neurons."
  第58回 日本神経化学会大会, 大宮ソニックシティ
• 2015年9月
  Kajita Y, Koganezawa N, Kojima N, Sakimura K, Sakurai T, Shirao T.
  "Drebrin knockout mice show olfactory dysfunction by impairment of adult neurogenesis and cell survival."
  第58回 日本神経化学会大会, 大宮ソニックシティ
• 2015年9月
  Yasuda H, Kojima N, Hanamura K, Shirao T.
  "Drebrin knockout mice show olfactory dysfunction by impairment of adult neurogenesis and cell survival."
  第58回 日本神経化学会大会, 大宮ソニックシティ
• 2015年7月
  Kajita Y. Koganezawa N, Kojima N, Sakimura K, Shirao T.
  "Drebrin knockout mice show the impairment of olfaction and adult neurogenesis."
  第38回 日本神経科学大会, 神戸国際会議場・神戸国際展示場
• 2014年11月
  Puspitasari A, Koganezawa N, Kojima N, Isono M, Yoshida Y, Shirao T.
  "Acute effect of X-irradiation and carbon ion-irradiation on fear memory formation and its underlying mechanism."
  The 41st Annual meeting of Society for Neuroscience, Walter E. Washington Convention Center, Washington, DC.
• 2014年9月
  Kojima N.
  "Maturation of cytoskeletal molecules in neurons: Drebrin is a key molecule for synaptic plasticity."
  ISN satellite symposium on "Key molecules for neuronal maturation", 東京大学弥生講堂
• 2014年9月
  Koganezawa N, Puspitasari A, Kojima N, Isono M, Yoshida Y, Shirao T.
  "The time-dependent effects of radiation on fear memory and synaptic proteins."
  第57回 日本神経化学会大会シンポジウム, 奈良県文化会館・奈良県新公会堂
• 2014年9月
  Kajita Y, Kojima N, Sakimura K, Shirao T.
  "Drebrin knockout mice show the olfaction impairment caused by delayed neural exchange in olfactory bulb."
  第37回 日本神経科学大会, パシフィコ横浜
• 2014年9月
  Koganezawa N, Kajita Y, Kojima N, Sakimura K, Shirao T.
  "Primary cultured hippocampal neurons prepared from drebrin knockout mouse shows the decrease of MAP2 positive dendrites at late developmental stage."
  第37回 日本神経科学大会, パシフィコ横浜
• 2014年9月
  Puspitasari A, Koganezawa N, Kojima N, Isono M, Yoshida Y, Shirao T.
  "Acute effect of carbon ion irradiation on hippocampal neuronal cell death and fear memory formation."
  第37回 日本神経科学大会, パシフィコ横浜
• 2014年9月
  Puspitasari A, Koganezawa N, Shuchuan M, Kojima N, Isono M, Yoshida Y, Kanai T, Shirao T.
  "Acute effect of Carbon Ion Irradiation on hippocampal neuron and fear memory formation."
  The 6th ISN 2014 Special Neurochemistry Conference, 東京大学弥生講堂
• 2014年9月
  Shirao T, Koganezawa N, Kajita Y, Kojima N, Sakimura K.
  "Primary cultured neurons prepared from drebrin knockout mice have a few MAP2 positive dendrites."
  第57回 日本神経化学大会, 奈良県文化会館・奈良県新公会堂
• 2013年11月
  Puspitasari A, Koganezawa N, Kojima N, Shirao T.
  "Acute effects of X-irradiation on learning, adult neurogenesis and the accumulation of drebrin."
  The 40th Annual meeting of Society for Neuroscience, San Diego Convention Center, California
• 2013年10月
  Kajita Y, Kojima N, Sakimura K, Shirao T.
  "Impairment of Adult Neurogenesis by Drebrin Knockout Results in the Olfactory Dysfunction."
  Brain and Health Informatics 2013, 前橋テルサ
• 2013年6月
  Puspitasari A, Koganezawa N, Kojima N, Shirao T.
  "Effect of X-irradiation on learning, cell death and synaptic proteins."
  第56回 日本神経化学会大会, 国立京都国際会館
• 2013年6月
  Kajita Y, Kojima N, Sakimura K, Shirao T.
  "Drebrin knockout mice show the impairment of olfactory acuity via affecting adult neurogenesis."
  第56回 日本神経化学会大会, 国立京都国際会館
• 2013年4月
  Kojima N.
  "Molecular and neuronal regulation of emotional memory: Age-related vulnerability to synaptic dysfunction in drebrin A-knockout mice."
  24th Biennial Meeting symposium, International Society for Neurochemistry, Cancun, Mexico