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原著論文 Original papers

  1. Naoki SASAKI, Chikako KASE, Masaki Chou, Genki NAKAZATO, Kae SATO
    "Mechanistic investigation of bead-based padlock rolling circle amplification under molecular crowding conditions"
    Analytical Biochemistry, 593, 113596 (2020).
  2. Shota YAMAMOTO, Kei OKADA, Naoki SASAKI, Alice Chinghsuan CHANG, Kazuo YAMAGUCHI, Jun NAKANISHI
    "Photoactivatable hydrogel interfaces for resolving the interplay of chemical, mechanical, and geometrical regulation of collective cell migration"
    Langmuir, 35(23), 7459-7468 (2019).
  3. Naoki SASAKI, Kimiaki TSUCHIYA, Hironori KOBAYASHI
    "Photolithography-free Skin-on-a-chip for Parallel Permeation Assays"
    Sensors and Materials, 31(1), 107-115 (2019).
  4. Hiroyoshi Y. Tanaka, Kentaro Kitahara, Naoki Sasaki, Natsumi Nakao, Kae Sato, Hirokazu Narita, Hiroshi Shimoda, Michiya Matsusaki, Hiroshi Nishihara, Atsushi Masamune, Mitsunobu R. Kano
    "Pancreatic stellate cells derived from human pancreatic cancer demonstrate aberrant SPARC-dependent ECM remodeling in 3D engineered fibrotic tissue of clinically relevant thickness"
    Biomaterials, 192, 355-367 (2019).
  5. Junya Yoshioka, Yu Ohsugi, Toru Yoshitomi, Tomoyuki Yasukawa, Naoki Sasaki, Keitaro Yoshimoto
    "Label-Free Rapid Separation and Enrichment of Bone Marrow-Derived Mesenchymal Stem Cells from a Heterogeneous Cell Mixture Using a Dielectrophoresis Device"
    Sensors, 18(9), 3007 (2018).
  6. 佐々木直樹, 林知美, 井上奈菜子, 大西真寛
    ”民生用レーザー加工機を用いる細胞培養マイクロ流体デバイスの作製”
    分析化学、67(7)、379-386 (2018)．
  7. Naoki SASAKI, Yoshitaka GUNJI, Chikako KASE, Kae SATO
    "Molecular crowding improves bead-based padlock rolling circle amplification"
    Analytical Biochemistry, 519, 15-18 (2017).
  8. Naoki SASAKI, Mariko TATANOU, Tomoko SUZUKI, Yasutaka ANRAKU, Akihiro KISHIMURA, Kazunori KATAOKA, Kae SATO
    "A Membrane-Integrated Microfluidic Device to Study Permeation of Nanoparticles through Straight Micropores toward Rational Design of Nanomedicines"
    Analytical Sciences, 32(12), 1307-1314 (2016).（注目論文選定）
  9. Kiichi SATO, Sayaka KIKUCHI, Eri YOSHIDA, Reina ISHII, Naoki SASAKI, Kin-ichi TSUNODA, Kae SATO
    "Patterned co-culture of live cells on a microchip by photocrosslinking with benzophenone"
    Analytical Sciences, 32(1), 113-116 (2016).
  10. Yuya USUI, Naoki SASAKI
    "Alternating Current Cloud Point Extraction on a Microfluidic Chip: the Use of Ferrocenyl Surfactants"
    Analytical Sciences, 32(1), 109-111 (2016).
  11. Miwa SATO, Naoki SASAKI, Manabu ATO, Satoshi HIRAKAWA, Kiichi SATO, Kae SATO
    "Microcirculation-on-a-chip: a microfluidic platform for assaying blood- and lymphatic-vessel permeability"
    PLOS ONE, 10(9), e0137301 (2015).
  12. Naoki SASAKI, Chisaki MAEKAWA, Kae SATO
    "Alternating current cloud point extraction on a microchip: the effect of electrode geometry"
    Electrophoresis, 36(3), 424-427 (2015).
  13. Naoki SASAKI, Jun-ichiro JO, Ichio AOKI, Kae SATO
    "Magnetic resonance imaging of a microvascular-interstitium model on a microfluidic device"
    Analytical Biochemistry, 458, 72-74 (2014).
  14. Kae SATO, Reina ISHII, Naoki SASAKI, Kiichi SATO, Mats NILSSON
    "Bead-based padlock rolling circle amplification for single DNA molecule counting"
    Analytical Biochemistry, 437(1), 43-45 (2013).

総説・解説 Reviews

  1. 杉本茉莉花、佐々木直樹
    Skin-on-a-chipの研究動向
    化学とマイクロ・ナノシステム、18(2)、21-22 (2019).
  2. 佐々木直樹
    生体に「まねぶ」バイオ分析
    工業技術, 40, 22-26 (2018).
  3. 佐々木直樹
    粒ぞろいの細胞もどきを作る
    ぶんせき、 6、215 (2016).
  4. 佐々木直樹、佐藤香枝
    マイクロ血管モデルの構築と分析化学的応用
    分析化学、65、241-247 (2016)．
  5. 佐々木直樹
    交流動電現象のマイクロチップバイオ分析への応用
    分析化学、64、1-8 (2015)．
  6. Kae SATO, Naoki SASAKI, Helene Andersson SVAHN, Kiichi SATO
    “Microfluidics for nano-pathophysiology”
    Advanced Drug Delivery Reviews, 74, 115-121 (2014).
  7. 佐々木直樹
    交流動電現象の学理と応用
    工業技術, 36, 68-72 (2014).

著書 Books

  1. 佐々木直樹
    第Ⅲ編第13章　無細胞マイクロ腫瘍血管モデルの開発とナノ薬剤評価への応用
    酒井康行・金森敏幸監修、臓器チップの技術と開発動向、シーエムシー出版、2018年4月25日.
  2. 佐々木直樹
    6章　液体および溶液の性質
    田島正弘・熊澤隆・吉田泰彦共編著、理工系学生のための基礎化学、培風館、2018年3月30日.

審査つきプロシーディング Conference proceedings (peer-reviewed)

  1. Marika Sugimoto, Keisuke Yanagisawa, Naoki Sasaki
    "A TWO-WAY MEMBRANE-INTEGRATED MICROFLUIDIC DEVICE FOR PERMEATION ASSAYS"
    Proceedings of Micro Total Analysis Systems 2019, 1128-1129 (2019).
  2. Mayu Watanabe, Yumi Moriya, Hiroaki Matsuba, Akihiro Kishimura, Yoshiki Katayama, Naoki Sasaki
    "EXTRAVASATION OF SOFT NANOPARTICLES SIMULATED ON AN EASY-TO-OBSERVE MEMBRANE-INTEGRATED MICROFLUIDIC DEVICE"
    Proceedings of Micro Total Analysis Systems 2019, 750-751 (2019).
  3. Marika Sugimoto, Fuka Nagatomi, Naoki Sasaki
    "A DUAL-MEMBRANE MICROFLUIDIC DEVICE FOR CELL MIGRATION ASSAY"
    Proceedings of Micro Total Analysis Systems 2018, 1525-1526 (2018).
  4. Yuki Ichikawa, Tomomi Hayashi, Naoki Sasaki
    "PHOTOLITHOGRAPHY-FREE TUMOR-ON-A-CHIP TO STUDY NANOPARTICLE EXTRAVASATION"
    Proceedings of Micro Total Analysis Systems 2018, 1473-1474 (2018).
  5. Yumi Moriya and Naoki Sasaki
    "A MEMBRANE-INTEGRATED MICROFLUIDIC DEVICE FOR SIMULATING NANOPARTICLE EXTRAVASATION IN TUMOR MICROENVIRONMENT"
    Proceedings of Micro Total Analysis Systems 2018, 2407-2408 (2018).
  6. Yumi MORIYA, Miki ODANAKA, Naoki SASAKI
    “Simulation of nanoparticle extravasation using an　easy-to-observe membrane-intgrated microfluidic device”
    Proceedings of Micro Total Analysis Systems 2017, 1211-1212 (2017).
  7. Satoshi WATANABE, Naoki SASAKI
    "FABRICATION OF AN EASY-TO-OBSERVE MEMBRANE-INTEGRATED MICROFLUIDIC DEVICE"
    Proceedings of Micro Total Analysis Systems 2016, 1023-1025 (2016).
  8. Naoki SASAKI, Mariko TATANOU, Yasutaka ANRAKU, Akihiro KISHIMURA, Kazunori KATAOKA, Kae SATO
    “Characterization of nanoparticle permeability on membrane-integrated microfluidic devices”
    Proceedings of Micro Total Analysis Systems 2013, 1818-1820 (2013).
  9. Miwa SATO, Naoki SASAKI, Satoshi Hirakawa, Kae SATO
    “Development of an ex-vivo lymphatic vascular model”
    Proceedings of Micro Total Analysis Systems 2013, 1093-1095(2013).

2012年度以前の成果

原著論文 Original papers

  1. Naoki SASAKI, Azusa TAKEMURA, Kae SATO
    “Alternating current cloud point extraction on a microchip: a comprehensive study”
    Electrophoresis, 33(21), 3159-3165 (2012).
  2. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “Fluid mixing using AC electrothermal flow on meandering electrodes in a microchannel”
    Electrophoresis, 33(17), 2668-2673 (2012).
  3. Naoki SASAKI, Mika SHINJO, Satoshi HIRAKAWA, Masahiro NISHINAKA, Yo TANAKA, Kazuma MAWATARI, Takehiko KITAMORI, Kae SATO
    “A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump”
    Electrophoresis, 33(12), 1729-1735 (2012).
  4. Naoki SASAKI, Anri ISU, Reina ISHII, Kae SATO
    “Photochemical immobilization of cells onto a glass substrate for in situ DNA analysis”
    Analytical Sciences, 28(6), 537-539 (2012).(掲載号表紙採用、注目論文選定)cover-28-06L.jpg
  5. Naoki SASAKI, Jiansheng GONG, Makoto SAKURAGI, Kazuo HOSOKAWA, Mizuo MAEDA, Yoshihiro ITO
    “Hydrodynamic cell pairing and cell fusion through a microslit on a microfluidic device”
    Japanese Journal of Applied Physics, 51(3), 030206 (2012).
  6. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “Experimental and theoretical characterization of AC electroosmotic micromixer”
    Analytical Sciences, 26(7), 815-819 (2010).
  7. Etsushi YAMAMOTO, Satoshi YAMAGUCHI, Naoki SASAKI, Haeng-Boo KIM, Takehiko KITAMORI, Teruyuki NAGAMUNE
    “Artificial chaperone-assisted refolding in a microchannel”
    Bioprocess and Biosystems Engineering, 33(1), 171-177 (2010).
  8. Naoki SASAKI, Kazuo HOSOKAWA, Mizuo MAEDA
    “Alternating current cloud point extraction on a microchip for preconcentration of membrane-associated biomolecules”
    Lab on a Chip, 9(9), 1168-1170 (2009).
  9. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “AC electroosmotic micromixer for chemical processing in a microchannel”
    Lab on a Chip, 6(4), 550-554 (2006).
  10. Haeng-Boo KIM, Tomokazu HAGINO, Naoki SASAKI, Noriyuki WATANABE, Takehiko KITAMORI
    “Spectroelectrochemical detection using thermal lens microscopy with a glass-substrate microelectrode-microchannel chip”
    Journal of Electroanalytical Chemistry, 577(1), 47-53 (2005).

総説・解説 Reviews

  1. Naoki SASAKI
    “Recent applications of AC electrokinetics in biomolecular analysis on microfluidic devices”
    Analytical Sciences, 28(1), 3-8 (2012).
  2. 佐々木直樹
    光誘起動電現象で生体分子を濃縮する
    ぶんせき, 7, 361 (2010).

審査つきプロシーディング Conference proceedings (peer-reviewed)

  1. Naoki SASAKI, Anri ISU, Reina ISHII, Kae SATO
    “Photo-immobilization of cells for in situ DNA analysis”
    Proceedings of Micro Total Analysis Systems 2012, 1252-1254 (2012).
  2. Naoki SASAKI, Azusa TAKEMURA, Kae SATO
    “Mechanistic characterization of alternating current cloud point extraction in a microchannel: extraction under physiological temperature”
    Proceedings of Micro Total Analysis Systems 2012, 896-898 (2012).
  3. Kae SATO, Mami NISHIKAWA, Naoki SASAKI, Kiichi SATO
    “Development of a microfluidic southern hybridization analysis system using microbeads”
    Proceedings of Micro Total Analysis Systems 2011, 296-298 (2011).
  4. Naoki SASAKI, Azusa TAKEMURA, Kae SATO
    “Mechanistic investigation of alternating current cloud point extraction in a microchannel”
    Proceedings of Micro Total Analysis Systems 2011, 218-220 (2011).
  5. Reina ISHII, Naoki SASAKI, Kiichi SATO, Kazuma MAWATARI, Mats NILSSON, Takehiko KITAMORI, Kae SATO
    “Counting single DNA molecule by on-bead rolling circle amplification for quantitative analyses”
    Proceedings of Micro Total Analysis Systems 2011, 70-72 (2011).
  6. Kae SATO, Yuri KITAMURA, Naoki SASAKI, Kiichi SATO, Kazuma MAWATARI, Mats NILSSON, Takehiko KITAMORI
    “Single DNA molecule detection by on-bead rolling circle amplification using microchip for efficient detection”
    Proceedings of Micro Total Analysis Systems 2010, 1460-1462 (2010).
  7. Naoki SASAKI, Jiangsheng GONG, Kazuo HOSOKAWA, Mizuo MAEDA, Yoshihiro ITO
    “Pairing and fusion of heterotypic cells in a microchannel”
    Proceedings of Micro Total Analysis Systems 2010, 687-689 (2010).
  8. Naoki SASAKI, Kazuo HOSOKAWA, Mizuo MAEDA
    “Analysis of fluid motion in alternating current cloud point extraction”
    Proceedings of Micro Total Analysis Systems 2009, 43-45 (2009).
  9. Naoki SASAKI, Kazuo HOSOKAWA, Mizuo MAEDA
    “AC electrokinetic phase separation, focusing and concentration in microchannel”
    Proceedings of Micro Total Analysis Systems 2008, 754-756 (2008).
  10. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “Rapid mixing by AC electrothermal flow”
    Proceedings of Micro Total Analysis Systems 2007, 916-918 (2007).
  11. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “AC electroosmotic micromixer: viscosity and ionic strength dependence of mixing time”
    Proceedings of Micro Total Analysis Systems 2006, 1103-1105 (2006).
  12. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “Rapid mixing based on AC electroosmosis in microchannel”
    Proceedings of Micro Total Analysis Systems 2005, 1096-1098 (2005).
  13. Naoki SASAKI, Takehiko KITAMORI, Haeng-Boo KIM
    “Space- and temporal-controlled electroorganic synthesis with glass electrochemical microchip”
    Proceedings of Micro Total Analysis Systems 2004, 457-459 (2004).
  14. Haeng-Boo KIM, Tomokazu HAGINO, Naoki SASAKI, Takehiko KITAMORI
    “Ultrasensitive detection of electrochemical reactions by thermal lens microscopy for microchip chemistry”
    Proceedings of Micro Total Analysis Systems 2003, 817-820 (2003).

特許 Patents

  1. 光架橋反応を利用したガラス基板への細胞固定化法、佐藤香枝、佐々木直樹、特願2012-83371、2012年3月
  2. マイクロミキサー及び流体の攪拌方法並びに流体の混合方法、金幸夫、北森武彦、佐々木直樹、特願2006-243584、2006年9月
  3. マイクロミキサー及び流体の攪拌方法並びに流体の混合方法、北森武彦、金幸夫、佐々木直樹、特願2005-148719、2005年5月
  4. 流体混合装置、北森武彦、金幸夫、佐々木直樹、特願2005-148720、2005年5月

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