Publication
Original Papers
Ishiuchi Y, Sato H, Komatsu N, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T. (2018) Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle.
Cytokine 108: 17-23
Ishiuchi Y, Sato H, Tsujimura K, Kawaguchi H, Matsuwaki T, Yamanouchi K, Nishihara M, Nedachi T. (2018) Skeletal muscle cell contraction reduces a novel myokine, chemokine (C-X-C motif) ligand 10 (CXCL10): Potential roles in exercise-regulated angiogenesis.
Biosci Biotech Biochem 82(1):97-105.
Ariga M, Yoneyama Y, Fukushima T, Ishiuchi Y, Ishii T, Sato H, Hakuno F, Nedachi T, Takahashi SI. (2017) Glucose deprivation attenuates sortilin levels in skeletal muscle cells.
Endocr J. 64(3):255-268.
Kawashima KI, Ishiuchi Y, Konnai M, Komatsu S, Sato H, Kawaguchi H, Miyanishi N, Lamartine J, Nishihara M, Nedachi T. (2016) Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.
FEBS Open Bio. 7(2):149-159.
Sato K, Yamanaka Y, Asakura Y, Nedachi T. (2016) Glutamate levels control HT22 murine hippocampal cell death by regulating biphasic patterns of Erk1/2 activation: role of metabolic glutamate receptor 5”
Biosci Biotech Biochem 80(4):712-8.
Ogura Y, Sato K, Kawashima K, Kobayashi N, Imura S, Fujino K, Kawaguchi H, Nedachi T. (2014) Subtoxic levels of hydrogen peroxide induce brain-derived neurotrophic factor expression to protect PC12 cells.
BMC Res Notes 7: 840
Sato K, Yamanaka Y, Ishii M, Ishibashi K, Ogura Y, Ohtani-Kaneko R, Nishihara M, Nedachi T. (2014) Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells.
Biosci Biotech Biochem 78(9): 1495-503
Sato T, Ito Y, Nedachi T, Nagasawa T (2014) Lysine suppresses protein degradation through autophagic-lysosomal system in C2C12 myotubes.
Mol Cell Biochem 391: 37-46
Fujino K, Ogura Y, Sato K, Nedachi T (2013) Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells.
Neurosci Lett 557(B): 148-153
Farmawati A, Kitajima Y, Nedachi T, Sato M, Kanzaki M, Nagatomi R (2013) Characterization of Contraction-induced IL-6 Up-regulation using contractile C2C12 myotubes.
Endocrine J 60(2):137-47
Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S (2012) Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.
Mol Endocrinol 26(6): 1043-55
Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M (2011) Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3beta phosphorylation.
Neuroscience 185: 106-115
Nedachi T, Matsuwaki T, Nishihara M (2011) Involvement of progranulin in modulating behavior and neurodegeneration.
Cognition and Dimentia 10(2): 44-50
Nedachi T, Matsuwaki T, Asakura R, Nishihara M (2010) Dementia-related gene, Progranulin
Japanese journal of geriatric psychiatry 21(5): 555-560
Nedachi T, Hatakeyama H, Kono T, Sato M, Kanzaki M (2009) Characterization of contraction-inducible CXC chemokines and their roles in C2C12 myocytes.
Am J Physiol Endocrinol Metab 297(4): E866-E878
Suzuki M, Lee HC, Kayasuga Y, Chiba S, Nedachi T, Matsuwaki T, Yamanouchi K, Nishihara M (2009) Roles of progranulin in sexual differentiation of the developing brain and adult neurogenesis.
J Reprod Dev 55(4): 351-355
Nedachi T, Kawai T, Nishihara M (2009) Growth factor progranulin and neurodegeneration
Experimental Medicine 27(9): 1345-1349 (Japanese)
Nedachi T, Fujita H, Kanzaki M (2008) Contractile C2C12 model for studying exercise-inducible responses in skeletal muscle.
Am J Physiol Endocrinol Metab 295(5): E1191-E1204
Fukushima T*, Nedachi T*, Akizawa H, Hakuno F, Takahashi SI (2008) Distinct modes of activation of phosphatidylinositol 3-kinase in response to cAMP or IGF-I play different roles in regulation of cyclin D1 and p27Kip1 in FRTL-5 cells. (*F.T. and N.T. contributed equally)
Endocrinology 149(7): 3729-3842
Nedachi T, Kadotani A, Ariga M, Katagiri H, Kanzaki M (2008) Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3A in C2C12 myocytes.
Am J Physiol Endocrinol Metab 294(4): E668-E678
Ariga M, Nedachi T, Katagiri H, Kanzaki M (2008) Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes.
J Biol Chem 283(15): 10208-10220
Ariga M, Nedachi T, Kanzaki M (2008) New Diabetology
Nippon Rinsyo 430-434 (Japanese)
Nedachi T (2007) Molecular evolution of docking proteins which controls a variety of physiological functions
Experimental Medicine 25 (16): 2518-2519
Nedachi T (2007) Ceramide synthesis and insulin resistance
Experimental Medicine 25(9): 1331-1332
Fujita H, Nedachi T, Kanzaki M (2007) Accelerated de novo sarcomere assembly by electrical pulse stimulation in C2C12 myotubes.
Exp Cell Res 313(9): 1853-1856
Nedachi T (2007) Resveratrol-dependent improvement of metabolic environment
Experimental Medicine 25(3): 381-382 (Japanese)
Han SJ, Vaccari S, Nedachi T, Andersen CB, Kovacina KS, Roth RA, Conti M (2006) Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation.
EMBO J 25(24): 5716-5725
Nedachi T, Kanzaki M (2006) Regulation of glucose transporters by insulin and extracellular glucose in C2C12 myotubes.
Am J Physiol Endocrinol Metab 291(4): E817-E828
Nedachi T (2006) Role of endogenous electric field on wound healing
Experimental Medicine 24 (16): 2498
Nedachi T (2006) New member for the determination of life span
Experimental Medicine 24(9): 1306-1307 (Japanese)
Nedachi T, Conti M (2004) Protein tyrosine phosphatase non-receptor type 13 is involved in oocyte meiotic resumption.
Development 131(20): 4987-4998
Masciarelli S, Horner K, Liu C, Park SH, Hinckley M, Hockman S, Nedachi T, Jin C, Conti M, Manganiello V (2004) Cyclic nucleotide phosphoesterase 3A-deficient mice as a model of female infertility.
J Clin Invest 114 (2): 196-205
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA (2003) Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
Biochem J 369 (Pt2): 227-238
Takahashi SI, Nedachi T, Fukushima T, Oki N, Umesaki K, Hakuno F, Ito Y, Van Wyk JJ, Conti M (2003) Proliferation of thyroid cells and cAMP specific phosphodiesterase
Clinical Endocrinology 50: 183-191 (Japanese)
Takahashi SI, Nedachi T, Fukushima T, Umesaki K, Ito Y, Hakuno F, Van Wyk JJ, Conti M (2002) Long tern hormonal regulation of cAMP specific phosphodiesterases in cultured FRTL-5 thyroid cells.
Biophys Biochem Acta 1540(1): 68-81
Nedachi T, Hakuno F, Takahashi SI (2001) Is endocrine insulin-like growth factor-I essential for postnatal growth? -A new prospectives of somatomedin hypothesis-
Endocrinology and Diabetology 11(4): 378-387
Nedachi T, Akahori M, Ariga M, Sakamoto H, Suzuki N, Umesaki K, Hakuno F, Takahashi SI (2000) Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3', 5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells.
Endocrinology 141(7): 2429-2438
Ariga M, Nedachi T, Akahori M, Sakamoto H, Ito Y, Hakuno F, Takahashi SI (2000) Signalling pathways of insulin-like growth factor I that are augmentated by cAMP in FRTL-5 cells.
Biochem J 348 (Pt2): 409-416
Koide T, Ono Y, Ito Y, Akahori M, Nedachi T, Hakuno F, Takenaka A, Takahashi SI, Noguchi T (1998) Insulin-like growth factor-I potentiates protein synthesis induced by thyrotropin in FRTL-5 cells: comparison of induction of protein synthesis and DNA synthesis.
Endocrine J 45(2): 151-163
