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原著論文

1.  Combined Heme Iron Supplementation and Nutritional Counseling Improves Sports Anemia in Female Athletes.

     Matsumoto M, Hagio M, Katsumata M and Noguchi T.

     Ann Sports Med Res. 2(6):1036, 2015


2.  Activity of ERK regulates mucin 3 expression and is involved in undifferentiated Caco-2 cell death induced by

     3-oxo-C12-homoserine lactone.

     Shimizu H, Baba N, Nose T, Taguchi R, Tanaka S, Joe GH, Maseda H, Nomura N, Hagio M, Lee JY, Fukiya S,

     Yokota A, Ishizuka S and Miyazaki H.

     Biosci Biotechnol Biochem. 79(6):937-42, 2015

3.  Inhibition of nestin suppresses stem cell phenotype of glioblastomas through the alteration of post-
     translational modification of heat shock protein HSPA8/HSC71.
     Matsuda Y, Ishiwata T, Yoshimura H, Hagio M, Arai T.
     Cancer Lett. 357(2):602-11, 2015


4.  Deoxycholic acid is involved in the proliferation and migration of vascular smooth muscle cells.

     Shimizu H, Hagio M, Iwaya H, Tsuneki I, Lee JY, Fukiya S, Yokota A, Miyazaki H, Hara H, Ishizuka S.

     J Nutr Sci Vitaminol. 60(6), 450-454, 2014


5.  Diet supplementation with cholic acid promotes intestinal epithelial proliferation in rats exposed to
     γ-radiation.
     Hagio M, Shimizu H, Joe GH, Takatsuki M, Shiwaku M, Xu H, Lee JY, Fujii N, Fukiya S, Hara H,
     Yokota  A, Ishizuka S.
  Toxicol Lett. 232(1):246-252, 2014


6.  Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats.
     Matsumoto M, Hagio M, Inoue R, Mitani T, Yajima M, Hara H, Yajima T.
     PLoS One. 9(4):e93529, 2014.

7.  Contribution of Dipeptidyl Peptidase IV to the Severity of Dextran Sulfate Sodium-Induced Colitis in
     the Early Phase.
     Iwaya H, Fujii N, Hagio M, Hara H, Ishizuka S.
     Biosci Biotechnol Biochem. 77(7):1461-6, 2013.

8.  Nestin: A novel angiogenesis marker and possible target for tumor angiogenesis.
     Matsuda Y, Hagio M, Ishiwata T.
     World J Gastroenterol. 19(1):42-8, 2013.

9.  Nestin regulates epithelial mesenchymal transition marker expression in pancreatic ductal
     adenocarcinoma cell lines.
     Hagio M, Matsuda Y, Suzuki T, Ishiwata T.
     Molecular and Clinical Oncology. 1(1):83-7, 2013.

10. Fibroblast Growth Factor Receptor 2 IIIc as a Therapeutic Target for Colorectal Cancer Cells.
      Matsuda Y, Hagio M, Seya T, Ishiwata T.
      Mol Cancer Ther. 11(9):2010-20, 2012.

11. Expression of Cancer Stem Cell Markers in Pancreatic Intraepithelial Neoplasias and Pancreatic Ductal
      Adenocarcinomas.
      Kure S, Matsuda Y, Hagio M, Ueda J, Naito Z, Ishiwata T.
      Int J Oncol. 41(4):1314-24, 2012.

12. Is bile acid a determinant of the gut microbiota on a high-fat diet?
      Yokota A, Fukiya S, Islam KB, Ooka T, Ogura Y, Hayashi T, Hagio M, Ishizuka S.
      Gut Microbes. 3(5):455-9, 2012.

13. Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP
      and increase in H2AX phosphorylation after exposure to g-rays.
      Ishizuka S, Shiwaku M, Hagio M, Suzuki T, Hira T, Hara H.
      Biomedical Research. 33(3):159-65, 2012.

14. Expression and roles of lumican, a small leucine-rich proteoglycan, in gastrointestinal and other
      cancers.
      Ishiwata T, Hagio M, Takayama R, Matsuda Y.
      J Gastroenterol Hepatol. 1(5):62-8, 2012.

15. Clinicopathological Features of Thirty Autopsy Cases of Pancreatic Carcinoma.
      Matsuda Y, Hagio M, Naito Z, Ishiwata T.
      J Nippon Med Sch. 79(6):459-67, 2012.

16. Bile Acid is a Host Factor that Regulates the Composition of the Cecal Microbiota in Rats.
      Islam KB, Fukiya S, Hagio M, Fujii N, Ishizuka S, Ooka T, Ogura Y, Hayashi T, Yokota A.
      Gastroenterology 141 (5):1773-81, 2011.

17. Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer; a
      potential therapeutic target in colorectal cancer.
      Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng W, Yamamoto T, Nakazawa
      N, Seya T, Ohaki Y, Naito Z.
      Cancer Lett. 309 (2) :209-19, 2011.

18. Voluntary wheel-running exercise and dietary lactose concomitantly reduce the proportion of
      secondary bile acids in rat feces.
      Hagio M, Matsumoto M, Yajima T, Hara H, Ishizuka S.
      J Appl Physiol. 109 (3) :663-8, 2010.

19. Inulin prolongs survival of intragastrically administered Lactobacillus plantarum no. 14 in the gut of
      mice fed a high-fat diet.
      Takemura N, Hagio M, Ishizuka S, Ito H, Morita T, Sonoyama K.
      J Nutr. 140 (11) :1963-9, 2010.

20. Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride
      absorption in lymph duct-cannulated rats.
      Matsumoto M, Hosokawa M, Matsukawa N, Hagio M, Shinoki A, Nishimukai M, Miyashita K,
      Yajima T, Hara H.
      Eur J Nutr. 49 (4) :243-9, 2010.

21. Nondigestible Saccharides Suppress the Bacterial Degradation of Quercetin Aglycone in the Large
      Intestine and Enhance the Bioavailability of Quercetin Glucoside in Rats.
      Matsukawa N, Matsumoto M, Shinoki A, Hagio M, Inoue R, Hara H.
      J Agric Food Chem. 57 (20) :9462-8, 2009.

22. Improved analysis of bile acids in tissues and intestinal contents of rats using LC/ESI-MS.
      Hagio M, Matsumoto M, Fukushima M, Hara H, Ishizuka S.
      J Lipid Res. 50 (1) :173-80, 2009.

23. Relationship between formation of aberrant crypts and acute responses of colonic epithelial cells to
      genotoxic treatment among inbred rat strains.
      Ishizuka S, Takeuchi A, Hagio M, Mohara M, Sakai H, Yamada K.
      Cancer Lett. 196 (2) :135-41, 2003.
 
著書
1.  Metabolic Profiling: Bile acid analysis in various biological samples using ultra performance liquid
     chromatography/electrospray-mass spectrometry (LC/ESI-MS) .
     Hagio M, Matsumoto M, Ishizuka S.
     Methods Mol Biol. 708:119-29, 2011.
 
学会発表
1.  Comparison of fermentation levels in large intestine of rats fed different carbohydrate diets by
     analyzing feces using LC/MS.
     Hagio M, Matsumoto M, Shinoki A, Yokota A and Ishizuka S
     20th International Congress of Nutrition. Spain, 2013. (poster)
    
2.  Tumor-forming ability of side population of pancreatic ductal adenocarcinoma cell.
     Hagio M, Matsuda Y, Kawamoto Y, Yanagisawa Y, Naito Z, Ishiwata T.
     18th international Charles Heidelberger Symposium on cancer research, Ulm, 2012. (poster)

3.  Comparison of tumor-forming ability in different fractions of pancreatic ductal adenocarcinoma cells.
     Hagio M, Matsuda Y, Kawamoto Y, Ishiwata T.
     American association for cancer research, 103rd annual meeting 2012, AACR, Chicago, 2012. (poster)

4.  Nestin modulates EMT molecules and transcription factors in human pancreatic cancer cells.
     Hagio M, Matsuda Y, Suzuki T, Naito Z, Ishiwata T.
     American Pancreatic Association Meeting, APA, Chicago, 2011. (poster)

5.  Treatments with diet and voluntary exercise influence bile acid composition in feces.
     Hagio M, Matsumoto M, Yajima T, Hara H, Ishizuka S.
     19th International Congress of Nutrition. Thailand, 2009. (poster)